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Melanin: Aging of the Skin and Skin Cancer

"Ultraviolet (UV) radiation is American Academy of Dermatology does not
responsible for 90% of the visible signs recommend their use.UV-B radiation, which
of aging on the skin of whites," says Dr. is partially filtered by the ozone,
Michael J. Martin, former Assistant penetrates the skin to the bottom layer
Clinical Professor in the Dept. of of the epidermis where the basal cells
Epidemiology and Biostatistics at are produced. UV-B can break the
University of California, San molecular bonds, disturbing the dividing
Francisco.Blacks' skin, however, ages cells and altering their structure.
much slower.Why are most dark-skinned Compared with UV-A, UV-B is responsible
blacks protected from harmful UV rays? for most of DNAs damage. It also causes
Because compared to whites, blacks most sunburns. During a sunburn the
possess more melanin, the pigment that reddening of the skin, erythema, is
gives skin its color.MelaninMelanin caused by dilation of capillaries.More
offers protection against UV rays for UV-B is present during summer months
blacks and other dark-skinned people. between 10 a.m. and 4 p.m. and at
Conversely, fair-skinned people are much latitudes closer to the equator.
less protected and more susceptible to Furthermore, at high altitudes the air is
skin cancer. Furthermore, albinos' skin thinner and cleaner, so UV-B radiation is
offers no protection.Although blacks' more abundant.UV-C, which is generally
skin produces more melanin than whites', filtered by the ozone, has the shortest
all skin has the same number of wavelength and the most energy, or
melanocytes, the cells that manufacture intensity. It can sterilize hospital
the melanin.Melanocytes manufacture equipment and kill bacteria.In addition,
melanin from an amino acid, tyrosin, with UV light that reaches the earth is
the help of an enzyme, tyrosinase. In the scattered in all directions, and up to
bottom layer of the epidermis above the 85% is reflected from surfaces.The Theory
dermis, UV light stimulates the of Melanin for Environmental
production of melanin in the form of AdaptationOriginally, people of a
insoluble melanosomes. These surround the particular race resided in a particular
epidermal cells, which move up to the area. As time went on, their skin adapted
surface of the skin. The result is a to the environment. For instance, people
tan.Blacks' skin produce more melanin, who lived geographically close to the
even in the absence of sunlight, and equator had darker skin, and people who
their type of melanin, eumelanin, is more lived far from the equator had lighter
effective at blocking solar rays. skin.In Scotland, which lies at a
However, white skin produces melanin only northern latitude, descendants of the
in the presence of sunlight and after the Britons have white skin. When their skin
UV rays have penetrated the lower portion is exposed to the meager sunlight, the
of the epidermis and have caused skin scant amount of melanin their skin
damage."Melanin also functions as an produces is unable to block the sunlight.
excellent free radical scavenger. It Therefore, their bodies are able to make
affects the delicately designed lipids Vitamin D with the help of sunlight.
that hold moisture in the stratum corneum Vitamin D, a vitamin found in fish oil,
(the outermost layer of the epidermis). is necessary to prevent rickets, a bone
If the skin loses its moisture, it disease caused by too little calcium.In
becomes rigid and cracks," says Sergio contrast, in Africa, which is near the
Nacht, PhD., Senior Vice-President of equator, blacks require intense sunlight
Enhanced Derm Technologies, Inc. in to penetrate their dark skin to make
Redwood City.UV Radiation and SkinUV-A Vitamin D. This is all well and good.
has the longest wavelength, is not However, when blacks lived in England
filtered by the ozone and passes through during the Industrial Revolution, they
glass. It reaches the earth all year long were the first to develop symptoms of
and the amount is comparatively stable. rickets, such as retarded growth, bowed
It can penetrate the skin down to the legs and fractures because not enough
dermis, beneath the four layers of sunlight was available.Fortunately, in
epidermis. It is responsible for most of 1930, Vitamin D was discovered and
the visible signs of aging, due to damage dispensed as a supplement to add to the
to collagen and elastic fibers of the diet.On the other hand, the skin of
connective tissue of the dermis.UV-A whites in Australia are in complete
radiation also plays a role in the opposition to their climate.
development of sunburns and skin cancer. Consequently, intense UV radiation has
Tanning salon lamps emit a large amount been the major cause of skin damage and
of UV-A rays to generate tans, so the skin cancer Down Under.




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